Metastatic Pulmonary Calcification: a rare complication of chronic renal disease

  • Criador do t贸pico RCAAP Rss Feeder
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RCAAP Rss Feeder

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Breve resumo:
Metastatic pulmonary calcification (MPC) is a silent metabolic lung disease that is commonly associated with end-stage renal disease. This condition is characterized by the deposition of calcium salts mainly in the epithelial membranes of the alveoli, being the computed tomography (CT) the most useful imaging method for its diagnosis. In this review, we describe a case of MPC in a 57-year-old patient with chronic renal disease waiting for his second kidney transplant. Chest computed tomography (CT) revealed bilateral, centrilobular ground-glass opacities and heterogeneous, high-density areas distributed over both upper lobes. When left untreated, lung opacities can get massively calcified or become progressively denser, as observed in this case. Bone scintigraphy may demonstrate radioisotope uptake, supporting the metastatic nature of the disease. The resolution of pulmonary calcification in chronic renal failure can occur after parathyroidectomy, renal transplantation, or dialysis. Therefore, the early diagnosis of this condition will be a benefit for the patients' outcome.​



Info Adicional:
Metastatic pulmonary calcification (MPC) is a silent metabolic lung disease that is commonly associated with end-stage renal disease. This condition is characterized by the deposition of calcium salts mainly in the epithelial membranes of the alveoli, being the computed tomography (CT) the most useful imaging method for its diagnosis. In this review, we describe a case of MPC in a 57-year-old patient with chronic renal disease waiting for his second kidney transplant. Chest computed tomography (CT) revealed bilateral, centrilobular ground-glass opacities and heterogeneous, high-density areas distributed over both upper lobes. When left untreated, lung opacities can get massively calcified or become progressively denser, as observed in this case. Bone scintigraphy may demonstrate radioisotope uptake, supporting the metastatic nature of the disease. The resolution of pulmonary calcification in chronic renal failure can occur after parathyroidectomy, renal transplantation, or dialysis. Therefore, the early diagnosis of this condition will be a benefit for the patients' outcome.



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